02.07.2018 16:15 Philipp Rinklin (TUM):
Thermally induced lesions and signal modulation in cardiomyocyte networksMI 03.06.011 (Boltzmannstr. 3, 85748 Garching)

In most biological systems, global average temperatures are a highly regulated and controlled quantity. As such, the majority of previous research regarding the influence of temperature on biological systems uses variations of ambient temperatures. Recent discussions, however, have highlighted the possibility of highly localized temperature gradients as an important factor in biological systems. In our research, we employ microstructured conductors to generate temperature gradients on the micrometer scale. As a biological model system, we culture cardiomyocyte-like cells on our chips. These cells show propagating waves in intracellular calcium concentration. In my presentation, I will illustrate how we use fluorescent methods to analyze the signal propagation in these networks. Further, I will introduce the application of highly localized temperature gradients to interrupt the propagation, influence the signal velocity, and relocate the signal origin in these networks.